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Despite the complex nature of the problem, the solution proved to be both simpler and more effective than the researchers thought. By developing a new so-called asymmetric organocatalytic reaction, Daniel Strand and his colleagues succeeded in the most inaccessible parts of the molecules.

It turned out that the real structure was the mirror image of we initially thought was glionitrin A. So, all this time we had chased a molecule that ," says Daniel Strand.

Complex natural products with unique properties such as glionitrin A and B are important tools in develop. Glionitrin A has shown antibiotic properties against resistant bacteria, while glionitrin B makes cancer cells less to migrate. Being able to produce the molecules synthetically helps researchers not only understand how they work, but also improve their properties. We expect our results to inspire further development basic synthetic chemistry but also to be used in drug development," concludes Daniel Strand.

Materials provided by Lund University. Note: Content may be edited for style and length. Science News. Story Source: Materials provided by Lund University. Journal Reference : Nicolas R. Koning, Anders P. Sundin, Daniel Strand. ScienceDaily, 6 December Lund University. Researchers crack the synthetic code of rare molecules sought after in drug development.

Retrieved January 13, from www.



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